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A Hero Ingredient To Help Manage Obesity

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A Hero Ingredient To Help Manage Obesity

Roselle Beads

Roselle extracts have been encapsulated into little beads. They are in a petri dish, which is being held by a blue-gloved hand. Credit: RMIT University

According to recent research, the antioxidants found in the roselle plant have been found to have anti-obesity properties and may offer a potential alternative in the form of food for current weight management medications.

Antioxidants in the roselle plant have anti-obesity properties that could help in food alternatives to current weight management medications, according to new research.

A study conducted by Ph.D. candidate Manisha Singh at RMIT University explored the potential of phenolic extracts (antioxidant compounds) and hydroxycitric acid (organic acid) found in the hardy roselle plant (Hibiscus sabdariffa) to prevent the creation of fat cells.

When the body has an excess of fat intake, fat can be deposited in the cell, which turns them into fat cells called adipocytes.

Fat Droplets in Adipocytes

A chart showing the fat droplets between a control adipocyte and an adipocyte that has been treated with phenolic extracts. The one that has been treated shows much less fat droplets. Credit: Manisha Singh

Adipocytes are vital for regulating the body’s energy and sugar levels. However, when energy intake exceeds expenditure, it can cause the fat cells to grow in both size and number, contributing to obesity.

Human stem cells were separately treated with phenolic extracts and hydroxycitric acid before they were turned into fat cells.

While cells treated with hydroxycitric acid showed no change in the fat content of the adipocytes, cells treated with phenolic extracts had 95% less fat as compared to control cells.

Singh’s research is the first of its kind to use human fat cells to test the impacts of phenolic extracts and hydroxycitric acid from roselle.

Singh’s Ph.D. supervisor Professor Benu Adhikari, from RMIT’s Food Research and Innovation Centre, said the results of the study could impact how we approach obesity management.

Current methods of obesity management focus on lifestyle changes and medication.

Benu Adhikari, Thilini Thrimawithana and Manisha Singh

Scientists Benu Adhikari, Thilini Thrimawithana and Manisha Singh looking at roselle samples while smiling. Credit: RMIT University

While medication is effective, they can also have negative side effects such as high blood pressure or impact the kidney and liver.

“The phenolic extracts from the roselle could help create a health food product that is effective in interfering with the formation of fat cells, but also bypass the bad side effects of some medications,” Adhikari said.

A natural enzyme blocker

Senior Lecturer Dr. Thilini Thrimawithana, from the School of Health and Biomedical Sciences, said there is a growing interest in researching how antioxidant-rich compounds, called polyphenols, could one day help manage diseases like obesity to avoid side effects of medications such as Orlistat and Liraglutide.

Polyphenols are found in food sources such as vegetables and fruits. When consumed, antioxidants remove the oxidation that forms in our bodies, which can help slow down aging and prevent diseases.

Singh’s research also found polyphenols in the roselle had similar digestive enzyme-inhibiting properties as some obesity management medications.

Roselle

Three Petri dishes, each filled with roselle beads, freeze-dried roselle flowers, and roselle powder. Credit: RMIT University

The polyphenols inhibit the digestive enzyme called lipase. This enzyme helps break down fats into small fractions so they are absorbed by the body through the intestine. The excess fats are turned into fat cells.

By inhibiting the lipase enzyme, the fat cannot be absorbed so it is passed through the colon as waste.

“Because these polyphenolic compounds are plant-derived and can be consumed, there should be fewer or no side effects,” Singh said.

Roselle Flowers

Freeze-dried roselle flowers in a petri dish. The dish is being held in blue-gloved hands. Credit: RMIT University

Next steps

Adhikari, a leading food researcher whose interest began as a farmer back in Nepal, predicts the roselle will play a bigger role in Australia’s health food industry.

“Australia has the perfect climate for farming the roselle. The plant is hardy, disease resistant and it doesn’t need a lot of space or water to grow,” he said.

Roselle Powder

Freeze-dried roselle flowers crushed into a powder. The powder is in a petri dish with a metal spoon scooping up some of the powder. Credit: RMIT University

The team plans to encapsulate the phenolic extracts for use in health food products. They say the extracts could be turned into little beads and used to make a refreshing drink.

“Phenolic extracts oxidize easily, so not only does encapsulation extend its shelf life, but it lets us control how they are released and absorbed by the body,” Adhikari said.

“If we don’t encapsulate the extract, it could break down in the stomach before we can reap its benefits.”

Reference: “Impact of phenolic extracts and potassium hydroxycitrate of Hibiscus sabdariffa on adipogenesis: a cellular study” by Manisha Singh, Thilini Thrimawithana, Ravi Shukla, Charles Stephen Brennan and Benu Adhikari, 23 December 2022, International Journal of Food Science & Technology.
DOI: 10.1111/ijfs.16269

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